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In addition, IGF-1 LR3 may promote fat breakdown by activating the MAPK pathway, leading to increased levels of free fatty acids and further exacerbating insulin resistance, forming a vicious cycle

The blue box indicates the putative N-terminal signal sequence, the green boxes denote putative N-glycosylation sites, the red box denotes the lipase motif (Gly-x-Ser-x-Gly), and the asterisks denotes the catalytic Ser-Asp-His triad that contains Sxxx

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