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Although an increased risk of pancreatitis is listed in product monographs for GLP-1RAs and caution should be exercised in individuals with a history of pancreatitis, causality has not been established [4, 66]
Peptides are small chains of amino acids that can mimic natural hormones in the body
Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations
This method of looking at the pros and cons is always the best way to look at any therapy but, when you do, make sure you take into account all pros and cons
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