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Inhibition of Nrf2 activity, depletion of intracellular GSH reserves, or induction of lipid peroxidation-associated ferroptosis have shown potential in preclinical studies to enhance chemosensitivity and reverse resistance [43, 44]

Jun 2007;65(6 Pt 1):286-293

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The glucagon arm, which sounds alarming on paper because glucagon raises blood sugar alone, did not derail glucose control inside the molecule