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When histamine remains elevated, it contributes to NMDA receptor overactivity , neuroinflammation, and impaired serotonin functionnot necessarily low serotonin production, but poor serotonin signaling and utilization
PubMed Central , Human Molecular Genetics , vol
Paroni R, De Vecchi E, Cighetti G, Arcelloni C, Fermo I, Grossi A et al
doi: 10.3390/nu11020451 26 GonzaliS.KiferleC.PerataP
These DAMPs draw in and activate immune cells, driving ICD
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