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Furthermore, commonly employed proteasome inhibitors, like MG132, are designed to affect both the 20S and 26S proteasomes (Lee and Goldberg, 1998), posing challenges in specifically studying substrates degraded exclusively by the 20S proteasome

25, 38 Identical results were also obtained for all cell lines tested with BSO+L-PAM when cultured in standard culture conditions (room air+5% CO 2

Pharmacists may spend significant time assisting patients in navigating these barriers, explaining cost differences, and identifying alternative pathways

Key red flags include pregnancy (no safety data, so contraindicated), active cancer (caution due to growth effects), autoimmune disorders, or organ failure