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Levine LA, Cuzin B, Mark S et al: Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's diease: a phase 3 open-label study

The table assumes subcutaneous injection at standard dosing (0.25-0.5 mg/day during loading)

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animals were sacrificed 2 h after the last injection (8 h drug exposure), and their hearts removed and tissue samples from left ventricular wall dissected