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Patients with higher initial HbA1c levels or greater insulin resistance may experience more dramatic improvements in blood glucose control, though these changes may take longer to fully develop

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In animal models, GLP-1R agonists prevent capillary rarefaction and microvascular barrier dysfunction and reduce apoptosis and reactive oxygen species in microvascular endothelial cells, contributing to improved organ function and reduced progression of microvascular complications [162]

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10 , R84 (2008)