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Each E2p subunit contains two consecutive lipoic acid-bearing domains (LBDs), termed as L1 and L2, one subunit binding domain (SBDp) which binds E1p and the inner-core/catalytic domain containing the E2 p active site responsible for the self assembly of the core which connects with the other independent domains by unstructured linkers [3](Fig.3)

OA activates the Nrf2/HO-1 pathway, increases GSH levels and SOD and CAT activities, and significantly reduces intracellular ROS accumulation [112]

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