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109 Several studies estimate the prevalence in the overall canine population to be as high as 20%, with possibly increased prevalence in some breeds

Research shows enhanced granulation tissue formation, improved re-epithelialization, increased collagen deposition, and superior dermal remodeling through VEGF pathway activation

Front Genet (2016) 7:136

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Copper has a complex role in oxidative biology participating in both prooxidant chemistry (where free or weakly bound copper can catalyze damaging reactive-oxygen-species generation) and antioxidant chemistry (as the cofactor of Cu/Zn superoxide dismutase)

The key takeaway is that side effects become far more manageable when you have the right medical team behind you and when the medication you receive meets human-grade pharmaceutical standards