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Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients

Female victims

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2012;7:e34268

These mutations lead to abnormal IDH2 enzyme activity, resulting in the production of the oncometabolite 2-hydroxyglutarate (2-HG), which affects cellular metabolism and epigenetic modifications, promoting tumorigenesis and progression [70, 71]