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This is by design: the short duration prevents the sustained GH elevation that would trigger negative feedback and somatostatin rebound

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James is a Trustee Scholar at the University of Southern California

[5] Exceeding that ceiling without demonstrated biochemical justification raises the theoretical risk of tachyphylaxis through GHRH receptor downregulation, though published pediatric data on this threshold are limited to case series rather than randomized trials

doi: 10.1016/j.molcel.2020.10.010 15 CaoZZhaoSHuSWuTSunFShiLI