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The binding of Ca 2+ promotes the interaction of the PH domain of PLC with PIP2 (Essen et al., 1997

These include improving clinical markers in neurodegenerative diseases, treating congestive heart failure, lowering cholesterol and blood sugar, minimising bone loss, and improving cognitive performance [4]

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466 In addition, larger nanoparticles have greater cellular uptake

Wallner M, Kolesnik E, Ablasser K, Khafaga M, Wakula P, Ljubojevic S, Thon-Gutschi EM, Sourij H, Kapl M, Edmunds NJ, Kuzmiski JB, Griffith DA, Knez I, Pieske B, von Lewinski D (2015) Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium