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Currently, another small molecule GLP-1R agonist called compound 29 (DA-302168S) has also shown good therapeutic potential (Dong et al., 2025)

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GLD-1 alone accounts for more than half of this repression, as LAG-1 level is elevated almost 3-fold in the gld-1 single null mutant, which is consistent with lag-1 mRNA being identified as a GLD-1 target in RNA pull-down experiments [44,45]

Additionally, because semaglutide reduces overall appetite and hedonic eating, it may indirectly weaken the behavioral overlap between food seeking and smokinga common relapse trigger in smokers attempting to quit

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