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These conformational changes are stabilized by additional noncovalent interactions involving the conserved residues, such as the Arg121 making hydrogen bonds with Asp67 to further strengthen the pi-cation interactions involving Trp72, Arg102, and Trp110 (see Figure 4 inset 2)

Gastrointestinal issues are usually strongest in first-time users, or when people step up to a larger dosage, but they usually dissipate over time

Raufman, J

27 (Suppl 1), S139S146 (2019)

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Food and Drug Administration (FDA), the most commonly reported side effects of these medications include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, bloating, belching, and flatulence