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Across modalities, reproducibility is limited by heterogeneity in formulation, dose, viability, and reporting

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It defends against free radicals produced within the mitochondria (power plants) of cells

In addition, the cases of oral hyperpigmentation reported to date do not appear to be drug dose-dependent (Table 2)

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These findings came from one research programme and require consideration of mouse strain, housing conditions, dose pattern and statistical methods