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Novel dual agonists for GLP-1/glucagon and GLP-1/GIP are being developed by the pharmaceutical industry and have demonstrated some promising results for weight loss and improvement in glycaemia over and above GLP-1 analogues

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Physiology-Gastrointestinal Liver Physiology 282 (3), G424G431

J Am Coll Cardiol (1995) 26:12354

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In particular, preclinical studies have demonstrated that GLP-1 and its more stable and long-lasting analogues GLP-1RAs possess neuroprotective and antiapoptotic properties, modulate long-term potentiation and synaptic plasticity, as well as promote the differentiation of neuron precursors, and can reduce depressive behavior [75]