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Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor gene), MC4R (a satiety-linked melanocortin receptor), and TCF7L2 (tied to glucose homeostasis) describe the baseline metabolism into which a dual agonist is introduced

they do not predict how you will respond to any specific drug, but they map the ground a clinician is prescribing into