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The progression of colitis was monitored using the Disease Activity Index (DAI) scoring system (Yao et al., 2020), which assesses the severity of colitis based on specific parameters
These observations support a paradigm, in which Ca 2+ /CaSR signaling counteracts PTHrP/PTH1R signaling by suppressing PTH1R expression, independently, of IGF1/IGF1R signaling and by inhibiting PTHrP expression via the IGF1/IGF1R pathway to support normal progression of chondrocyte differentiation and growth plate development (Figure 1)
In addition, individual compounds of the herbal extracts are barely studied even in experimental animal models
PubMed PMID: 18071657
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