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how could this peptide have any systemic activity

The FDA didnt just approve it, it championed it

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Some common side effects that have been reported in the existing research include: Mild injection site reactions (e.g., redness, swelling, or pain) Nausea Occasional headaches It is important to recognize that individual responses to DSIP may vary, and some people may experience side effects not listed here

People with very low B12 levels might also get a B12 injection at the recommendation of their GP

It is non-addictive and does not cause withdrawal (some people worry they cant sleep without it, but thats usually because their underlying insomnia returns, not because of dependency)