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Most existing cardiovascular outcome trials were not designed with BP as the primary outcome, and variations in BP measurements, drug doses, and trial designs limit cross-study comparisons

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Thats one reason obesity is increasingly treated as a chronic condition rather than a short-term project

Trauma or injury may be a risk factor

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The external adverse elements, such as cigarette smoking, physical damage, and microbiota influence, may cause keratinocytes damaged through excessive production of ROS(Plenkowska et al., 2020)