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The tesofensine article covers a compound that approaches weight loss through neurotransmitter modulation, providing appetite suppression through a completely different mechanism than GLP-1 agonists

The main gap is the absence of dietitian access , which means the behavioral and nutritional support side of the program relies on provider consultations rather than dedicated nutrition professionals

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doi: 10.1016/j.brainres.2007.02.043, 90

Short-term use (1-2 weeks) may be sufficient for some, while others may require longer periods (4-6 weeks or more) to achieve their goals

Effect of Metformin on Short-Term High-Fat Diet-Induced Weight Gain and Anxiety-like Behavior and the Gut Microbiota