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A common starting dose is 50 mg once daily for 4-6 weeks

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Tirzepatide (which activates both GLP-1 and GIP receptors) may cause slightly more appetite suppression initially, potentially requiring closer attention to protein intake

Cravings continue to diminish

Unlike stimulant appetite suppressants, semaglutide restores your body's natural satiety pathway, making normal portion sizes feel genuinely satisfying rather than forcing willpower

After excessive stretching over a long period, the skin loses its natural elasticity (the essential skin protein that helps your skin retract.) Other factors can also influence elasticity, like age (you make less elastin as you age) and genetics