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Circadian disruption in beta-Bmal1(-/-) mice and arrhythmic Clock 19 mice decrease the Nrf2 expression and subsequently impair the antioxidant defense system, contributing to increased ROS accumulation, oxidative damage and mitochondrial uncoupling

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Symptoms might include unusual fatigue, weight gain, mood changes, or increased susceptibility to infections

Cortisol (stress hormone) is: Anti-inflammatory (short-term good) Anti-healing (long-term bad) Optimize: Meditation, breathwork Nervous system regulation Reduce chronic stressors 6

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SURMOUNT-1 reported up to 20 to 22% weight reduction at the maximum 15 mg dose over 72 weeks