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Every clinical trial protocol started all participants at 1mg weekly, regardless of their target maintenance dose

Badulescu S, Tabassum A, Le GH, et al

Slowed gastric emptying sends signals to the brain to decrease food intake and can therefore help to control energy consumption

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[26] GLP-1 exerts its metabolic effects through activation of GLP-1 receptors (GLP-1R) distributed throughout multiple organ systems, including the pancreas, brain, gastrointestinal tract, and cardiovascular system