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Functionally verifying the incretin receptor-dependent nature of the molecule, GLP-1GIPLani decreased body weight, food intake and blood glucose in DIO wild-type mice, and these effects were absent in DIO DIR-knockout mice (Fig
Complementing these findings, a separate trial assessing the efficacy of exenatide for alcohol use disorder also showed no significant difference in heavy drinking days overall
Study 2 was a 68-week trial that enrolled 1,961 patients with obesity (BMI greater than or equal to 30 kg/m2) or with overweight (BMI 27 to 29.9 kg/m2) and at least one weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension
