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Burciu RG, Fritsche N, Granert O, Schmitz L, Spnemann N, Konczak J, et al

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Elevated levels of B12 could be indicative of certain health concerns, Vettel says, including: Cancer Diabetes Impaired kidney function Liver disease If you have elevated levels of B12, your doctor may run other tests to determine the underlying cause

Some patients experience fatigue followed by gradual improvement as their body responds to treatment

The speed at which you experience a pick-me-up after a B12 injection can vary depending on a few factors: The Severity of Your Deficiency If you have a mild deficiency, you might feel a difference in energy levels within a few days to a week