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Activated SIRT1 interrupts TLR4/NF-B/STAT axis, reduces cytokine production by inactivated immune cells, and inhibits pro-inflammatory factors derived from macrophages/mast cells, such as platelet-activating factor and TNF- ( RSV-SIRT1 interaction modifies SIRT1 structure and promotes binding activity with its substrates including p65/RelA (Yeung et al., 2004), a component of the NF-B complex, which regulates activation of leukocytes and inflammatory cytokines

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The beams reach the layer of fatty tissue directly underneath the skin