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We don't define disease by an anthropometric measurement in anything else other than rare endocrinologic diseases

Weight loss is consistently attenuated in patients with T2DM a pattern replicated across the incretin class

Cole K, Woodford C, Alpert N, et al

Results vary based on starting weight, adherence to lifestyle changes, and individual metabolism

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Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158