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Activated M1 (or pro-inflammatory) microglia are part of an inflammatory cascade that includes upregulation of pro-inflammatory genes, release of pro-inflammatory cytokines, and generation of ROS, which may, under prolonged conditions, contribute to the neuroinflammation observed in AD brain [97]

These shifts happen independently of any supplement

Because both medications affect digestion and appetite regulation, gastrointestinal symptoms are the most commonly reported side effects

Institutional protocols discard vials at 28 days regardless of remaining volume, prioritizing data integrity over cost savings

The most obvious visual indicator is change in appearance

Getting the dosage and frequency right is crucial to see benefits while staying safe