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Syn-RA16 had a high binding affinity (Kd ~ 24.75 nM), akin to the previously documented RA16 aptamer, and displayed dose-dependent suppression of cell viability, with IC50 values around 118.4 nM

( e ) Lipidomic profiling of intestinal crypts from WT and HMGCS2 iKO mice under KD conditions

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