Canto C, Menzies KJ, Auwerx J
Respecting that timeline is what separates reproducible research from protocols that work once and fail twice
Estrogen is synthesized in the following tissues:[ref] ovaries (major source in women, E2) testes (males) fat cells (E1, especially post-menopause) brain liver pancreas intestines adrenals The precursor for estrogen is cholesterol, which is first converted (using CYP11A1) into progesterone, which is then converted (using CYP17A1) into androstenedione
Bruinstroop, E., van der Spek, A
Galanin Galanin is a neuropeptide in the central nervous system
For a detailed discussion of these criteria, we refer readers to the April 7, 2000 final rule (65 FR 18457 through 18458)