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Participants were also not on medications to treat osteoporosis

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In addition, long-term use of GLP-1RAs may also have potential safety risks, such as pancreatitis (Shetty et al., 2022) and thyroid diseases ( 6 Discussion T2DM is a chronic disease characterized by hyperglycemia, which eventually leads to microvascular damage and macrovascular events, as well as complications related to peripheral vascular diseases

Whether that premium is worth it depends on whether you value the specific additional ingredients enough to pay for them, and on whether you accept that ingredient-level evidence does not guarantee the finished blend works the same way

In annual filings to state regulators for plan year 2025, some insurers cited increases in utilization of GLP-1 drugs as a contributor to rising premiums

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