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The theoretical rationale centers on several observations

The American Psychiatric Association, Washington, DC Grant BF, Goldstein RB, Saha TD, Chou SP, Jung J, Zhang H, Pickering RP, Ruan WJ, Smith SM, Huang B, Hasin DS (2015) Epidemiology of DSM-5 alcohol use disorder: results from the national epidemiologic survey on alcohol and related conditions III

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2.2.2 Modulation of the expression of relevant hormone receptors affects endometrial metamorphosis The collaborative function of progesterone (P4) and estradiol (E2) is essential for establishing endometrial tolerance during the implantation window period in the natural reproductive cycle of mice (Gudelska et al., 2023)

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