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Current therapies target vasomotor tone but fail to prevent proliferation and remodeling, underscoring the need for novel interventions

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Wegovy is FDA approved for weight loss and maintenance in children 12 years and older who are obese as well as some adults who are overweight and have weight-related health issues

The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes

In clinical trials, patients achieved weight loss of approximately 15-20% from baseline after 72 weeks, with results varying by dose and whether patients had diabetes

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