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Lactic acidosis has been reported in approximately 32% of metformin overdose cases [see WARNINGS AND PRECAUTIONS ]

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Interestingly, IR, inflammation, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, autophagy, and the ubiquitinproteasome system (UPS), independently contribute to the onset and aetiopathogenesis of both T2DM and PD

A few examples: Berberine may enhance glucose lowering and interact with drug-metabolizing enzymes

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