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Beyond rebuilding, the peptide regulates matrix metalloproteinases (MMPs) in a way that clears out damaged tissue while protecting new collagen from breakdown

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Chemical promotion of HGF functions (enhanced receptor binding-affinity and nitration resistance) opens a new perspective from which the therapeutic effectiveness of HGF drugs and their effective tissue-specific delivery could be improved

therefore, some level of safety in human subjects can be assumed

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Increased generation of reactive oxygen species (ROS) when the heart muscle's oxygen supply is restored (reperfusion) might be an important contributor to myocardial damage occurring during ischemia-reperfusion (36)