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The rationale behind considering a microdosing approach, which could involve taking semaglutide every 5 days or more frequently in smaller amounts, is primarily focused on: Minimizing Side Effects: Semaglutides powerful effects on gastric emptying and appetite can sometimes lead to uncomfortable gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation, especially during dose escalation

In 2014, the FDA approved semaglutide (ozempic) for type 2 diabetes

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Effects of liraglutide on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: A systematic review and meta-analysis