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The effect of retatrutide on bone density is also yet to be seen, although other GLP-1s have been shown to cause a decrease in bone density proportional to weight loss

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The bupropion component carries an FDA boxed warning for increased suicidal ideation in young adults, similar to other antidepressants

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However, effectiveness depends on your dose, medical history, side effects, and lifestyle changes

Shift from Compounded Alternatives: During previous shortages, patients turned to compounded versions of these drugs offered by companies like Hims & Hers and Noom