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[Editors note: as of this writing, there are no generic versions of either semaglutide or tirzepatide approved by the FDA] Semaglutide functions as a GLP-1 receptor agonist, placing it in the same class of medications as tirzepatide, albeit with a more focused mechanism of action

The studies varied somewhat (I2=49%), and a leave-one-out sensitivity analysis showed 0% heterogeneity after excluding the EXSCEL trial (Fig

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