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Insider's takeaway Vitamin B12 injections are for those with a severe B12 deficiency or conditions that prevent their body from effectively absorbing the vitamin, Moreno says

Many find that injecting before a quiet evening or bedtime reduces the immediate itch-related stress, because you can rest through the worst few hours and reassess in the morning

High-dose pyridoxine may reduce the effectiveness of some medications

Generally, insured patients pay less than the retail cost

Other treatments include retinoids and azelaic acid , which can help in reducing pigmentation and promoting skin turnover

Vitamin B12 and Folate July 16, 2026 Key points Vitamin B12 and folate are vitamins that serve important functions in the human body