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This "step therapy" approach, common in pharmaceutical benefit management, could make orforglipron the default first-line GLP-1 therapy for many patients, with injectable options reserved for orforglipron non-responders or patients with specific clinical needs for higher efficacy

Similarly, a Danish registry study observed lower risks of corticosteroid initiation and hospital admissions among GLP-1RA users (102)

Patience and consistency are essential for success with peptide treatments

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In some embodiments, an otic high viscosity formulation or device is administered as monotherapy for treatment of an otic disease or condition described herein

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