Pizzuti D, Bortolami M, Mazzon E et al (2004) Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet
TB-500 (Thymosin Beta-4) upregulates actin, a cell-building protein involved in tissue repair and blood vessel growth
From there, maintenance is typically one injection every four to twelve weeks depending on diet, absorption and how the response holds
Support collagen synthesis Enhances the structural integrity of joints, tendons, and connective tissues
Human studies exist for Thymosin Beta-4 (not always TB-500) in wound healing (topical for venous ulcers, dry eye, epidermolysis bullosa), with Phase II/III trials showing safety and modest dermal benefits
Any weight changes during its study would likely be secondary to other effects, not a primary mechanism