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A series of randomized controlled trials by Jensterle and colleagues published between 2014 and 2022 established that liraglutide outperformed metformin on weight loss, menstrual frequency, and androgen reduction in women with obesity and PCOS.[6] It produces less weight loss than semaglutide or tirzepatide, but it carries the longest PCOS-specific track record of the three

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By this point, substantial new collagen has been deposited, elastin fibers have increased, and extracellular matrix remodeling has progressed meaningfully

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