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GLP-1 is an incretin hormone that enhances insulin secretion in response to meals and promotes satiety

However, their side effects might overlap or worsen in some cases

Accompanying gastrointestinal symptoms that suggest more serious conditions require medical assessment

10.1038/s41551-017-0077 6 AguadoB

However, the theoretical basis for combination therapy appears sound: one drug reduces fat absorption while the other reduces appetite and caloric intake, addressing two separate steps in weight gain

Brands like Ledisa are marketed this way, and none of these ingredients has been shown to drive meaningful weight loss when delivered through a patch