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In landmark mouse studies, oral 5-amino-1MQ produced robust reductions in adipocyte size, body fat and inflammatory adipokines while leaving food intake unchanged pointing to a fundamentally novel metabolic-rejuvenation mechanism that operates entirely on the methylationNAD axis

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10.1002/2211-5463.12402 125 WangC.-K.YangS.-C.HsuS.-C.ChangF.-P.LinY.-T.ChenS.-F.et al (2017)