CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial
First, to a 1.5-mL Eppendorf tube were added 25 L of GSH (12 mM), 45 L of CDNB (3.0 mM), 50 L of GST (appropriate concentration), and 200 L of triethanolamineHCl buffer (20 mM, pH 6.5), and then, the mixed solution was incubated for 60 min at 25 C
After reconstitution with bacteriostatic water, refrigerate at 28C and use within ~28 days
Studies in animals with GIP knockout genes have shown different results depending on the deleted exon
Storage Conditions: Keep tightly closed and store at 5-30C (41-86F)
Heterologous expression in vitro unveiled its constitutive activity capable to raise intracellular cAMP levels through Gs (321) and lead to the secretion of GLP-1 and PYY (89)