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Inhibition of the target gene expression can occur through various mechanisms such as RNA interference, once the sense-antisense mRNA duplex has formed, transcriptional interference, in which the NAT can act as a physical barrier for RNA polymerase activity, or epigenetic methylation of the sense gene DNA, thus inhibiting the transcription of the sense mRNA transcript [55, 56]

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Similarly, "leaky gut" (increased intestinal permeability) can allow undigested food particles and bacterial toxins to pass into the bloodstream, potentially leading to systemic inflammation and indirect contributions to malodor