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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]

These nutrients help regenerate and support glutathione levels in the body, improving antioxidant activity and overall cellular protection

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Br J Clin Pharmacol 35:409412 Semis HS, Kandemir FM, Kaynar O, Dogan T, Arikan SM (2021) The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats

The oxidative inactivation of human alpha-1 proteinase inhibitor

As interest in this enzyme grew, researchers began developing experimental compounds capable of interacting with NNMT in controlled laboratory environments