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Gally CR, Reis GS, Lima EC, Puchana MJ, Adebayo MA, Dotto GL

doi: 10.1021/acsnano.4c04674 174

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Free Radic Biol Med 188:146161

Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress

Furthermore, glutathione is strictly required for the biochemical synthesis of DNA building blocks