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Systematic reviews note that existing human data comes largely from small observational studies or case reports, many with methodological limitations

Lipedema is a progressive inflammatory disease that specifically targets fat deposits in the extremities and the pelvic torso

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adults currently use GLP-1 for weight loss Obesity rate: Declined from 39.9 percent (2022) to 36.4 percent (2026) based on self-reported BMI Diabetes diagnosis rate: Stable since 2023 after 15 years of gradual rise Important limitation: Self-reported data

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